M2N12

CAT: 0804-HY-128769-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-128769-02Size:5 mg

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Description

M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09 μM. M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of 0.53 μM and 1.39 μM, respectively. M2N12 has anti-tumor activity and can be used for cancer research[1].

CAS Number

2376577-06-7

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m2n12.html

Concentration

10mM

Purity

98.19

Solubility

DMSO : 11.11 mg/mL (ultrasonic; warming; heat to 67°C)

Smiles

O=C(C(Cl)=C1NCC2=CN(CC3=CC=C(C)C=C3)N=N2)C4=C(N=CC=C4)C1=O

Molecular Formula

C20H16ClN5O2

Molecular Weight

393.83

References & Citations

[1]Jing L, et al. Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. Eur J Med Chem. 2019 Sep 14;183:111696.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

CID 139600304

CAS Number	2376577-06-7
PubChem CID	139600304
IUPAC Name	6-chloro-7-[[1-[(4-methylphenyl)methyl]triazol-4-yl]methylamino]quinoline-5,8-dione
Molecular Formula	C20H16ClN5O2
Molecular Weight	393.8
XLogP	3
Topological Polar Surface Area	89.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Heavy Atom Count	28
Formal Charge	0
Complexity	647

SMILES

CC1=CC=C(C=C1)CN2C=C(N=N2)CNC3=C(C(=O)C4=C(C3=O)N=CC=C4)Cl

InChI

InChI=1S/C20H16ClN5O2/c1-12-4-6-13(7-5-12)10-26-11-14(24-25-26)9-23-18-16(21)19(27)15-3-2-8-22-17(15)20(18)28/h2-8,11,23H,9-10H2,1H3

InChIKey

BDBIMDYALUJAPR-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2376577-06-7

CID: 139600304

Formula: C20H16ClN5O2

MW: 393.8

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	393.8
XLogP3	3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	393.0992525
Monoisotopic Mass	393.0992525
Topological Polar Surface Area	89.8 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	647
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
M26288-01	M2N12

M2N12

Chemical Information

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