Fas/CD95, Human (HEK293, Fc)

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Alternative Products

Cat	Name
MBS8113618-01	Human Fas/CD95 HEK293 Overexpression Lysate
MBS8113618-02	Human Fas/CD95 HEK293 Overexpression Lysate
MBS8113619-01	Human Fas/CD95 HEK293 Overexpression Lysate
MBS8113619-02	Human Fas/CD95 HEK293 Overexpression Lysate
MBS8116305-02	Mouse Fas/CD95 HEK293 Overexpression Lysate
MBS8117353-01	Rat Fas/CD95 HEK293 Overexpression Lysate
MBS8117354-01	Rat Fas/CD95 HEK293 Overexpression Lysate
MBS8117354-02	Rat Fas/CD95 HEK293 Overexpression Lysate
MBS8117950-01	Cynomolgus Fas/CD95 HEK293 Overexpression Lysate
MBS8117353-02	Rat Fas/CD95 HEK293 Overexpression Lysate

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804-HY-P73047

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Fas/CD95, Human (HEK293, Fc)

UNSPSC Description: Fas receptor is a cell surface death receptor, can bind to Fas ligand to form death-inducing signaling complexes, such as Fas associated death domain proteins (FADD)[1][2]. Fas receptor participates in the caspase cascade and regulate the activation of JNK and p38-K downstream. It is also involved in the signaling cascade of ERK/JNK MAPKs, activating MAPK3/ERK1, MAPK8/JNK and NF-κB, which has been implicated in the pathogenesis of various malignant tumors and immune system diseases[3][4]. Human Fas receptor contain a death domain (230-314 a.a.) that plays a key role in regulating programmed death. Fas/CD95 Protein, Human (HEK293, Fc) has a full length of 173 amino acids (M1-N173), produced in HEK293 cells with C-terminal hFc-tag.
Type: Recombinant Proteins
Assay Protocol: https://www.medchemexpress.com/cytokines/fas-cd95-protein-human-hek293-fc.html
Smiles: MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK CRRCRLCDEG HGLEVEINCT RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE HGIIKECTLT SNTKCKEEGS RSN
Molecular Weight: 55-60 kDa
References & Citations: [1]Liu C, et al. Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation. Biochem J. 1995 Sep 15;310 ( Pt 3)(Pt 3):957-63.|[2]Screaton RA, et al. Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5211-6.|[3]Brenner B, et al. Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases. Cell Death Differ. 1998 Jan;5(1):29-37.|[4]Lee SM, et al. Stimulation of Fas (CD95) induces production of pro-inflammatory mediators through ERK/JNK-dependent activation of NF-κB in THP-1 cells. Cell Immunol. 2011;271(1):157-62.|[5]Park DR, et al. Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages. J Immunol. 2003 Jun 15;170(12):6209-16.
Shipping Conditions: Room temperature

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Our range of products, including Fas/CD95, Human (HEK293, Fc), falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

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Cat	Name
HY-P7168-02	Fas/CD95, Human (HEK293)
HY-P7168-01	Fas/CD95, Human (HEK293)
HY-P76330-02	Fas/CD95, Cynomolgus (HEK293)
HY-P70329-02	Fas/CD95, Human (HEK293, His)
HY-P70329-01	Fas/CD95, Human (HEK293, His)
HY-P73047	Fas/CD95, Human (HEK293, Fc)
HY-P76330-03	Fas/CD95, Cynomolgus (HEK293)
HY-P76330-04	Fas/CD95, Cynomolgus (HEK293)
HY-P76330-01	Fas/CD95, Cynomolgus (HEK293)
HY-P78296-02	Fas/CD95, Mouse (HEK293, Fc)