Fluorescent Human SSTR2 Full Length Protein (VLP)

Fluorescent Human SSTR2 Full Length Protein (VLP)

• Background: Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an invaluable drug target for the pharmacological management of pituitary adenomas and neuroendocrine tumors. Somatostatin receptors (SSTR1, 2A and B, 3, 4 and 5) belong to the G protein coupled receptor family and have a wide expression pattern in both normal tissues and solid tumors. Investigating the function of each SSTR in several tumor types has provided a wealth of information about the common but also distinct signaling cascades that suppress tumor cell proliferation, survival and angiogenesis. This provided the rationale for developing multireceptor-targeted somatostatin analogs and combination therapies with signaling-targeted agents such as inhibitors of the mammalian (or mechanistic) target of rapamycin (mTOR). The ability of SSTR to internalize and the development of rabiolabeled somatostatin analogs have improved the diagnosis and treatment of neuroendocrine tumors.
• Description: Fluorescent Human SSTR2 Full Length Protein (VLP) (SS2-HF2G3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ile 369 (Accession # P30874-1).
• Specifications: This protein carries a GFP tag.
• Expression Region: Met 1 - Ile 369
• Host: HEK 293
• Target: SSTR2
• Conjugation: GFP Fusion
• Tag: GFP Tag
• Source: Human
• Stability: The product MUST be stored at -70°C or lower upon receipt; -70°C for 12 months under sterile conditions.
• Endotoxin: 1.0 EU per μg
• Bioactivity: Immobilized Fluorescent Human SSTR2 Full Length Protein (VLP) (Cat. No. SS2-HF2G3) at 1 μg/mL (100 μL/well) can bind Anti-SSTR2 Antibody, Human IgG1 with a linear range of 0.1-4 ng/mL (QC tested).
• Format: Liquid
• Buffer: PBS, Arginine, pH7.4
• Additives: Trehalose
• Shipping Conditions: Dry ice
• Storage Conditions: -70°C, aviod light