Human IL-28 R alpha / IFN-lambda R1 Protein, His Tag

Human IL-28 R alpha / IFN-lambda R1 Protein, His Tag

• Background: IL-28 R alpha (Interleukin-28 receptor subunit alpha) also known as IFNLR1 (IFN-lambda receptor 1), it heterodimerizes with another subunit, IL-10RB, to form a type II cytokine receptor ,which binds IL-28A, IL-28B and IL-29. These ligands, which are distantly related to class I in terferons, are activated upon viral infection and trigger the JAK-STAT signaling pathway to exert antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts.
• Description: Human IL-28 R alpha, His Tag (ILR-H52H9) is expressed from human 293 cells (HEK293). It contains AA Arg 21 - Ala 228 (Accession # Q8IU57-1).
• Specifications: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.5 kDa. The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expression Region: Arg 21 - Ala 228
• Host: HEK 293
• Target: IL-28 R alpha
• Conjugation: Unconjugated
• Tag: C-10×His
• Source: Human
• Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Endotoxin: 1.0 EU per μg
• Purity: 95%
• Format: Powder
• Buffer: PBS, pH7.4
• Additives: Trehalose
• Molecular Weight: 25.5 kDa
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C