Human LILRA4 / CD85g / ILT7 Protein, His Tag (MALS verified)
CAT:
716-LI4-H5243-100ug
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Human LILRA4 / CD85g / ILT7 Protein, His Tag (MALS verified)
- Background: Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4/ILT7/CD85g) is a marker of plasmacytoid dendritic cells (pDCs), which are reported to be a major source of the abnormally high levels of IFNα associated with autoimmune diseases. Targeting LILRA4 with therapeutic antibodies to promote killing of these IFNα-producing pDCs is being investigated as a novel approach to alleviating the symptoms of autoimmune diseases. LILRA4 is an immunoglobulin-like protein preferentially expressed on the surface of human plasmacytoid dendritic cells (pDCs). It interacts with bone marrow stromal cell antigen 2 to control the Toll-like receptor (TLR) driven response by pDCs to viral infection. It may also be involved in modulating pDC-tumour interactions. pDCs are a source of the excess IFNα which drives autoimmune disease symptoms.
- Description: Human LILRA4, His Tag (LI4-H5243) is expressed from human 293 cells (HEK293). It contains AA Glu 24 - Asn 446 (Accession # P59901-1).
- Specifications: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 48.5 kDa. The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Expression Region: Glu 24 - Asn 446
- Host: HEK 293
- Target: LILRA4
- Conjugation: Unconjugated
- Tag: N-10×His
- Source: Human
- Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Endotoxin: 1.0 EU per μg
- Purity: 95%
- Bioactivity: Immobilized Human LILRA4, His Tag (Cat. No. LI4-H5243) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-LILRA4 Antibody, Human IgG1 with a linear range of 0.001-0.008 μg/mL (QC tested).
- Format: Powder
- Buffer: PBS, pH7.4
- Additives: Trehalose
- Molecular Weight: 48.5 kDa
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C