GPX4-IN-6
CAT:
804-HY-155664-03
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
GPX4-IN-6
- CAS Number: 2922824-07-3
- UNSPSC Description: GPX4-IN-6 (Compound C25) is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM. GPX4-IN-6 (Compound C25) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) [1].
- Target Antigen: Ferroptosis; Glutathione Peroxidase
- Type: Reference compound
- Related Pathways: Apoptosis;Metabolic Enzyme/Protease
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/gpx4-in-6.html
- Solubility: DMSO : 50 mg/mL (ultrasonic)
- Smiles: O=C(CBr)N(C1=CC(OC)=C(F)C(OC)=C1)C2=CC(OCCO3)=C3C=C2
- Molecular Weight: 426.23
- References & Citations: [1]Chen T, et al. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66(14):10036-10059.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported