Cynomolgus CLEC4C / BDCA2 Protein, His Tag (MALS verified)

Cynomolgus CLEC4C / BDCA2 Protein, His Tag (MALS verified)

• Background: CLEC4C (C-type lectin domain family 4 member C), also known as BDCA2, CLECSF11, CLECSF7, DLEC and CD303. Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cell. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.
• Description: Cynomolgus CLEC4C, His Tag (CLC-C52H4) is expressed from human 293 cells (HEK293). It contains AA Tyr 48 - Ile 212 (Accession # A0A2K5UWP4-1).
• Specifications: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 26.1 kDa. The protein migrates as 30-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expression Region: Tyr 48 - Ile 212
• Host: HEK 293
• Target: CLEC4C
• Conjugation: Unconjugated
• Tag: N-10×His
• Source: Cynomolgus
• Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Endotoxin: 1.0 EU per μg
• Purity: 95%
• Bioactivity: Immobilized Cynomolgus CLEC4C, His Tag (Cat. No. CLC-C52H4) at 1 μg/mL (100 μL/well) can bind Litifilimab with a linear range of 0.06-2 ng/mL (QC tested).
• Format: Powder
• Buffer: PBS, pH7.4
• Additives: Trehalose
• Molecular Weight: 26.1 kDa
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C