Setileuton (tosylate)

• Description :

  Setileuton tosylate is an inhibitor for 5-lipoxygenase, that inhibits the oxidation of arachidonic acid by recombinant human 5-LO, and the production of LTB4 in calcium ionophore-stimulated human whole blood, with IC50 of 3.9 and 52 nM, respectively[1].

• CAS Number :

  [1137737-87-1]

• Product Name Alternative :

  MK-0633 (tosylate)

• UNSPSC :

  12352211

• Target :

  Lipoxygenase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/setileuton-tosylate.html

• Smiles :

  O=S(O)(C1=CC=C(C=C1)C)=O.O=C2C=C(C3=CC=C(C=C3)F)C4=CC=C(CNC5=NN=C([C@](CC)(O)C(F)(F)F)O5)C=C4O2

• Molecular Formula :

  C29H25F4N3O7S

• Molecular Weight :

  635.58

• References & Citations :

  [1]Ducharme Y, et al., The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor. ACS Med Chem Lett. 2010 Apr 13;1 (4) :170-4.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported