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Setileuton (tosylate)

CAT: 0804-HY-10437ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10437ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Setileuton tosylate is an inhibitor for 5-lipoxygenase, that inhibits the oxidation of arachidonic acid by recombinant human 5-LO, and the production of LTB4 in calcium ionophore-stimulated human whole blood, with IC50 of 3.9 and 52 nM, respectively[1].
CAS Number
1137737-87-1
Product Name Alternative
MK-0633 (tosylate)
UNSPSC
12352211
Target
Lipoxygenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/setileuton-tosylate.html
Smiles
O=S(O)(C1=CC=C(C=C1)C)=O.O=C2C=C(C3=CC=C(C=C3)F)C4=CC=C(CNC5=NN=C([C@](CC)(O)C(F)(F)F)O5)C=C4O2
Molecular Formula
C29H25F4N3O7S
Molecular Weight
635.58
References & Citations
[1]Ducharme Y, et al., The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor. ACS Med Chem Lett. 2010 Apr 13;1 (4) :170-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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