Cynomolgus LAG-3 / CD223 Protein, Fc Tag (MALS verified)

• Background:

  Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.

• Description:

  Cynomolgus LAG-3, Fc Tag (LA3-C5252) is expressed from human 293 cells (HEK293) . It contains AA Ala 18 - His 449 (Accession # XP_005570011.1) .

• Specifications:

  This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 73.0 kDa. The protein migrates as 85-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• Accession Number:

  XP_005570011.1

• Expression Region:

  Ala 18 - His 449

• Host:

  HEK293

• Target:

  LAG-3

• Conjugation:

  Unconjugated

• Tag:

  C-Fc

• Source:

  Cynomolgus

• Stability:

  ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

• Endotoxin:

  1.0 EU per μg

• Purity:

  90%

• Bioactivity:

  Immobilized Cynomolgus LAG-3, Fc Tag (Cat. No. LA3-C5252) at 2 μg/mL (100 μL/well) can bind Anti-Human LAG3 MAb, Human IgG1 with a linear range of 8-31 ng/mL (QC tested).

• Format:

  Powder

• Buffer:

  Tris with Glycine, Arginine and NaCl, pH7.5

• Additives:

  Trehalose

• Molecular Weight:

  73.0 kDa

• Shipping Conditions:

  RT

• Storage Conditions:

  -20°C

• Package Size:

  100ug*1

• Species:

  Cynomolgus