Cynomolgus / Rhesus macaque PD-L1 / B7-H1 Protein, Fc Tag (MALS verified)

Cynomolgus / Rhesus macaque PD-L1 / B7-H1 Protein, Fc Tag (MALS verified)

• Background: Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.
• Description: Cynomolgus / Rhesus macaque PD-L1, Fc Tag (PD1-C5253) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Arg 238 (Accession # F6VEW6-1). In the region Phe 19 - Arg 238, the AA sequence of Cynomolgus and Rhesus macaque PD-L1 are homologus.
• Specifications: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.8 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expression Region: Phe 19 - Arg 238
• Host: HEK 293
• Target: PD-L1
• Conjugation: Unconjugated
• Tag: C-Fc
• Source: Cynomolgus / Rhesus macaque
• Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Endotoxin: 1.0 EU per μg
• Purity: 95%
• Format: Powder
• Buffer: PBS, pH7.4
• Additives: Trehalose
• Molecular Weight: 51.8 kDa
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C