Influenza A [A/Darwin/9/2021 (H3N2)] Neuraminidase (NA) Protein, His Tag (MALS & SPR verified)

Influenza A [A/Darwin/9/2021 (H3N2)] Neuraminidase (NA) Protein, His Tag (MALS & SPR verified)

• Background: Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell.
• Description: Influenza A [A/Darwin/9/2021 (H3N2)] Neuraminidase (NA) Protein, His Tag (NE2-V5249) is expressed from human 293 cells (HEK293). It contains AA Lys 80 - Ile 469 (Accession # EPI_ISL_2233240, GISAID).
• Specifications: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 51 kDa. The protein migrates as 70-90 kDa and 170 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expression Region: Lys 80 - Ile 469
• Host: HEK 293
• Target: Neuraminidase/NA (Influenza Virus)
• Conjugation: Unconjugated
• Tag: N-10×His
• Source: Influenza
• Stability: The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
• Endotoxin: 1.0 EU per μg
• Purity: 90%
• Format: Liquid
• Buffer: PBS, pH7.4
• Additives: Trehalose
• Molecular Weight: 51 kDa
• Shipping Conditions: Dry ice
• Storage Conditions: -70°C