3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine

3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine

• CAS Number: 1445379-59-8
• UNSPSC Description: 3'-O-(t-Butyldimethylsilyl)-2'-deoxy-2'-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/3-o-t-butyldimethylsilyl-2-deoxy-2-fluorouridine.html
• Purity: 91.46
• Solubility: 10 mM in DMSO
• Smiles: F[C@@H]1[C@H](O[Si](C)(C(C)(C)C)C)[C@@H](CO)O[C@H]1N2C(NC(C=C2)=O)=O
• Molecular Weight: 360.45
• References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported