Cyclotheonellazole A

CAT: 0804-HY-P3356Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-P3356Size:1 Each

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Description

Cyclotheonellazole A is a natural macrocyclic peptide and a potent elastase inhibitor (IC50=0.034 nM) . Cyclotheonellazole A inhibits chymotrypsin with an IC50 value of 0.62 nM[1][2].

CAS Number

2094993-48-1

UNSPSC

12352005

Target

Elastase; Proteasome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cyclotheonellazole-a.html

Solubility

10 mM in DMSO

Smiles

CCC[C@@H]1NC([C@H](CNC([C@@H](NC(/C=C/C2=CSC([C@@H](NC(C([C@@H](NC1=O)[C@H](CC)C)=O)=O)CC3=CC=C(C=C3)O)=N2)=O)CS(=O)(O[Na])=O)=O)NC([C@@H](NC(CNC(C4=CC=C(C=C4)O)=O)=O)C)=O)=O

Molecular Formula

C44H54N9NaO14S2

Molecular Weight

1020.07

References & Citations

[1]Cui Y, et al. Elastase Inhibitor Cyclotheonellazole A: Total Synthesis and In Vivo Biological Evaluation for Acute Lung Injury. J Med Chem. 2022;65 (4) :2971-2987.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Catalog	Name
GTR19220019-01	Cyclotheonellazole A

Cyclotheonellazole A

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