Cyclotheonellazole A

Cyclotheonellazole A

• CAS Number: 2094993-48-1
• UNSPSC Description: Cyclotheonellazole A is a natural macrocyclic peptide and a potent elastase inhibitor (IC50=0.034 nM). Cyclotheonellazole A inhibits chymotrypsin with an IC50 value of 0.62 nM[1][2].
• Target Antigen: Elastase; Proteasome
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cyclotheonellazole-a.html
• Solubility: 10 mM in DMSO
• Smiles: CCC[C@@H]1NC([C@H](CNC([C@@H](NC(/C=C/C2=CSC([C@@H](NC(C([C@@H](NC1=O)[C@H](CC)C)=O)=O)CC3=CC=C(C=C3)O)=N2)=O)CS(=O)(O[Na])=O)=O)NC([C@@H](NC(CNC(C4=CC=C(C=C4)O)=O)=O)C)=O)=O
• Molecular Weight: 1020.07
• References & Citations: [1]Cui Y, et al. Elastase Inhibitor Cyclotheonellazole A: Total Synthesis and In Vivo Biological Evaluation for Acute Lung Injury. J Med Chem. 2022;65(4):2971-2987.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported