UDP-glucosamine (disodium)

UDP-glucosamine (disodium)

• CAS Number: 1355005-51-4
• UNSPSC Description: UDP-glucosamine (UDP-GlcNAc) disodium is a substrate for O-GlcNAc transferase, which catalyzes the attachment of O-GlcNAc to proteins. O-GlcNAcase catalyzes the removal of O-GlcNAc from proteins. UDP-glucosamine (UDP-GlcNAc) disodium is the end product of the hexosamine biosynthesis pathway, which is regulated primarily by glucose-6-phosphate-Glutamine:fructose-6-phosphate amidotransferase (GFAT)[1].
• Target Antigen: Endogenous Metabolite; OGT
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/udp-glucosamine-disodium.html
• Solubility: H2O : 250 mg/mL (ultrasonic)
• Smiles: O[C@H]1[C@@](N2C(NC(C=C2)=O)=O)([H])O[C@@H]([C@H]1O)COP(OP(O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3N)O)O)CO)(O[Na])=O)(O[Na])=O
• Molecular Weight: 609.28
• References & Citations: [1]Chatham JC, Young ME, Zhang J. Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications. Curr Opin Pharmacol. 2021;57:1-12.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported