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Mezagitamab

CAT: 0804-HY-P99730-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99730-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mezagitamab (TAK-079) is a IgG1λ anti-CD38 monoclonal antibody. Mezagitamab depletes tumor cells expressing CD38 through antibody and complement dependent cytotoxicity. Mezagitamab has potential application in relapsed/refractory multiple myeloma (RRMM) and idiopathic thrombocytopenic purpura (ITP) [1][2][3].
CAS Number
2227490-52-8
Product Name Alternative
TAK-079
UNSPSC
12352203
Target
Apoptosis; CD38
Type
Inhibitory Antibodies
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mezagitamab.html
Purity
99.79
Solubility
10 mM in DMSO
Smiles
[Mezagitamab]
Molecular Weight
(143.7 kDa)
References & Citations
[1]Abadier M, et al. Mezagitamab induces immunomodulatory effect in patients with relapsed/refractory multiple myeloma (RRMM) [J]. Blood, 2020, 136: 9.|[2]Jadoon Y, et al. Immunotherapy in multiple myeloma. Cancer Treat Res Commun. 2021;29:100468. |[3]Kuter DJ. Novel therapies for immune thrombocytopenia. Br J Haematol. 2022 Mar;196 (6) :1311-1328. |[4]Roepcke S, et al., Pharmacokinetics and pharmacodynamics of the cytolytic anti-CD38 human monoclonal antibody TAK-079 in monkey - model assisted preparation for the first in human trial. Pharmacol Res Perspect. 2018 Jun;6 (3) :e00402.|[5]Korver W, et al., A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys. J Pharmacol Exp Ther. 2019 Aug;370 (2) :182-196.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3

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