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MGS0039

CAT: 0804-HY-123411Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123411Size:1 Each
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Description
MGS0039 is a type II group mGluR antagonist. MGS0039 has a high affinity for mGluR2 and mGluR3, with Ki values of 2.2 nM and 4.5 nM, respectively. MGS0039 can attenuate the inhibitory effect of glutamate-induced cyclic AMP formation triggered by Forskolin in CHO cells expressing mGluR2/mGluR3. MGS0039 shows antidepressant-like activity in rats[1].
CAS Number
569686-87-9
Product Name Alternative
BCI 632
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mgs0039.html
Smiles
O=C(O)[C@]1([C@@]2([C@](F)([C@@]2(C[C@H]1OCC3=CC=C(C(Cl)=C3)Cl)[H])C(O)=O)[H])N
Molecular Formula
C15H14Cl2FNO5
Molecular Weight
378.18
References & Citations
[1]Chaki S, et al. MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity. Neuropharmacology. 2004 Mar;46 (4) :457-67.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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