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2-Hydroxybutyric acid

CAT: 0804-HY-113381-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-113381-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2-Hydroxybutyric acid (α-Hydroxybutyric acid) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite[1]. 2-Hydroxybutyric acid is a potential biomarker for type 2 diabetes and preeclampsia[2][4]. 2-Hydroxybutyric acid prevents the acetaminophen (AP) -induced liver injury[3].
CAS Number
600-15-7
Product Name Alternative
α-Hydroxybutyric acid
UNSPSC
12352211
Hazard Statement
H315, H318, H335
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2-hydroxybutyric-acid.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 50°C) |H2O : ≥ 300 mg/mL
Smiles
CCC(O)C(O)=O
Molecular Formula
C4H8O3
Molecular Weight
104.10
Precautions
H315, H318, H335
References & Citations
[1]Landaas S, et al. The formation of 2-hydroxybutyric acid in experimental animals. Clin Chim Acta. 1975 Jan 6;58 (1) :23-32.|[2]Shantavasinkul PC, et al., Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid. Surg Obes Relat Dis. 2018 Aug;14 (8) :1126-1132.|[3]Zheng N, et al., Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid. J Pharm Anal. 2020 Dec;10 (6) :560-570.|[4]Wang F, et al., Metabolomic analysis-identified 2-hydroxybutyric acid might be a key metabolite of severe preeclampsia. Open Life Sci. 2023 Feb 28;18 (1) :20220572.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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