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Merestinib

CAT: 0804-HY-15514-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15514-01Size:5 mg
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Description
Merestinib (LY2801653) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib (LY2801653) also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM) [1][2].
CAS Number
1206799-15-6
Product Name Alternative
LY2801653
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
C-Met/HGFR; Discoidin Domain Receptor; FLT3; ROS Kinase
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LY2801653.html
Purity
99.99
Solubility
DMSO : ≥ 32 mg/mL
Smiles
O=C(C1=CC=C(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=CC5=C(N(C)N=C5)C=C4C6=CNN=C6)C(F)=C3
Molecular Formula
C30H22F2N6O3
Molecular Weight
552.53
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Yan SB, et al. LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models. Invest New Drugs. 2013 Aug;31 (4) :833-44.|[2]Barat S, et al. Targeting c-MET by LY2801653 for treatment of cholangiocarcinoma. Mol Carcinog. 2016 Jan 12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
BioRxiv. 2024 May 8:2024.05.07.592424.|Cancer Discov. 2016 Dec;6 (12) :1334-1341.|Clin Cancer Res. 2020 Jun 1;26 (11) :2615-2625.|Curr Res Microb Sci. 2025 Oct 18;9:100494.|Patent. WO2017019702A1.|Methods Mol Biol. 2018:1711:351-398.

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