Vaccarin

• Description :

  Vaccarin is an orally active flavonoid glycoside with multiple biological functions. Vaccarin promotes neovascularization by activating AKT and ERK. Vaccarin activates the AMPK signaling pathway to improve insulin resistance and steatosis. Vaccarin is a MAPK, NF-κB, and NFAT inhibitor, effectively blocking RANKL-induced osteoclastogenesis[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  Akt; AMPK; ERK; JNK; NF-κB; Nuclear Factor of activated T Cells (NFAT) ; p38 MAPK

• Type :

  Natural Products

• Related Pathways :

  Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/vaccarin.html

• Purity :

  98.47

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C1C=C(C2=CC=C(O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C=C2)OC4=CC(O)=C([C@H]5[C@@H]([C@H]([C@@H]([C@@H](CO)O5)O)O)O[C@H]6[C@@H]([C@H]([C@H](CO6)O)O)O)C(O)=C14

• Molecular Formula :

  C32H38O19

• Molecular Weight :

  726.63

• Precautions :

  H315, H319

• References & Citations :

  [1]Xie F, et al. Vaccarin promotes endothelial cell proliferation in association with neovascularization in vitro and in vivo. Mol Med Rep. 2015 Jul;12 (1) :1131-6.|[2]Lei Y, et al. Vaccarin ameliorates insulin resistance and steatosis by activating the AMPK signaling pathway. Eur J Pharmacol. 2019 May 15;851:13-24.|[3]Liu Y, et al. Vaccarin prevents titanium particle-induced osteolysis and inhibits RANKL-induced osteoclastogenesis by blocking NF-κB and MAPK signaling pathways. J Cell Physiol. 2019 Aug;234 (8) :13832-13842.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [53452-16-7]