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Vaccarin

CAT: 0804-HY-N1419-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N1419-01Size:5 mg
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Description
Vaccarin is an orally active flavonoid glycoside with multiple biological functions. Vaccarin promotes neovascularization by activating AKT and ERK. Vaccarin activates the AMPK signaling pathway to improve insulin resistance and steatosis. Vaccarin is a MAPK, NF-κB, and NFAT inhibitor, effectively blocking RANKL-induced osteoclastogenesis[1][2][3].
CAS Number
[53452-16-7]
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Akt; AMPK; ERK; JNK; NF-κB; Nuclear Factor of activated T Cells (NFAT) ; p38 MAPK
Type
Natural Products
Related Pathways
Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/vaccarin.html
Purity
98.47
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=C(O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C=C2)OC4=CC(O)=C([C@H]5[C@@H]([C@H]([C@@H]([C@@H](CO)O5)O)O)O[C@H]6[C@@H]([C@H]([C@H](CO6)O)O)O)C(O)=C14
Molecular Formula
C32H38O19
Molecular Weight
726.63
Precautions
H315, H319
References & Citations
[1]Xie F, et al. Vaccarin promotes endothelial cell proliferation in association with neovascularization in vitro and in vivo. Mol Med Rep. 2015 Jul;12 (1) :1131-6.|[2]Lei Y, et al. Vaccarin ameliorates insulin resistance and steatosis by activating the AMPK signaling pathway. Eur J Pharmacol. 2019 May 15;851:13-24.|[3]Liu Y, et al. Vaccarin prevents titanium particle-induced osteolysis and inhibits RANKL-induced osteoclastogenesis by blocking NF-κB and MAPK signaling pathways. J Cell Physiol. 2019 Aug;234 (8) :13832-13842.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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