(Rac)-Hesperetin-13C,d3

(Rac)-Hesperetin-13C,d3

• CAS Number: 2750534-85-9
• UNSPSC Description: (Rac)-Hesperetin-13C,d3 is the 13C- and deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.
• Target Antigen: Apoptosis; Autophagy; Isotope-Labeled Compounds; p38 MAPK
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;Autophagy;MAPK/ERK Pathway;Others
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer; Neurological Disease
• Purity: 99.3
• Solubility: 10 mM in DMSO
• Smiles: O=C1CC(C2=CC=C(O[13C]([2H])([2H])[2H])C(O)=C2)OC3=CC(O)=CC(O)=C13
• Molecular Weight: 306.29
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.|[2]Arya A, et al. Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism. Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:954-964|[3]Li Q, et al. Hesperetin Induces Apoptosis in Human Glioblastoma Cells via p38 MAPK Activation. Nutr Cancer. 2019 Jul 11:1-8.|[4]Liu D, et al. Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions. Biol Pharm Bull. 2016;39(12):2052-2059.|[5]Shagirtha K, et al. Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats. Toxicol Ind Health. 2016 Nov 1. pii: 0748233716665301
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported