AH2-14c

• Description:

  AH2-14c is an inhibitor for DNA demethylase ALKBH2. AH2-14c inhibits the cell viability (IC50 is 4.56 µM) and migration of GBM U87. AH2-14c regulates the expression of apoptosis-related genes, and induces apoptosis in GBM U87 cell[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Histone Demethylase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ah2-14c.html

• Purity:

  98.01

• Solubility:

  DMSO : 12.5 mg/mL (ultrasonic)

• Smiles:

  CC(C)(C)C(NC(C1=CC=C(N2N=CC(C(OCC)=O)=C2)N=C1)=O)C3=CC=CC=C3

• Molecular Formula:

  C23H26N4O3

• Molecular Weight:

  406.48

• References & Citations:

  [1]Xu K, et al., Discovery and structure-activity relationship study of nicotinamide derivatives as DNA demethylase ALKBH2 inhibitors. Eur J Med Chem. 2025 Jan 15;282:117054.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported