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FPFT-2216

CAT: 0804-HY-145319-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145319-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α) . FPFT-2216 can be used for the research of cancer and inflammatory disease[1][2].
CAS Number
2367619-87-0
UNSPSC
12352005
Target
Casein Kinase; Molecular Glues; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PROTAC; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fpft-2216.html
Purity
99.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(N1N=NC(C2=CSC=C2OC)=C1)CC3)NC3=O
Molecular Formula
C12H12N4O3S
Molecular Weight
292.32
References & Citations
[1]Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65 (1) :747-756.|[2]Gemechu Y, et al. Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs. Proc Natl Acad Sci U S A. 2018;115 (46) :11802-11807.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1; PDE6

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