FPFT-2216

• Description :

  FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α) . FPFT-2216 can be used for the research of cancer and inflammatory disease[1][2].

• CAS Number :

  [2367619-87-0]

• UNSPSC :

  12352005

• Target :

  Casein Kinase; Molecular Glues; Phosphodiesterase (PDE)

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PROTAC; Stem Cell/Wnt

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/fpft-2216.html

• Purity :

  99.75

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C(N1N=NC(C2=CSC=C2OC)=C1)CC3)NC3=O

• Molecular Formula :

  C12H12N4O3S

• Molecular Weight :

  292.32

• References & Citations :

  [1]Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65 (1) :747-756.|[2]Gemechu Y, et al. Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs. Proc Natl Acad Sci U S A. 2018;115 (46) :11802-11807.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CK1; PDE6