GSA-10

• UNSPSC Description:

  GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development[1][2][3].

• Target Antigen:

  Hedgehog; Smo

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/gsa-10.html

• Purity:

  98.01

• Solubility:

  DMSO : 1.67 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(OCCC)C1=CC=C(NC(C2=C(O)C3=C(N(CCCCCC)C2=O)C=CC=C3)=O)C=C1

• Molecular Weight:

  450.53

• References & Citations:

  [1]Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol Pharmacol. 2013 May;83(5):1020-9. |[2]Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem. 2016 Oct 4;121:747-757. |[3]Fleury A, et al. Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci Rep. 2016 Mar 24;6:23479. doi: 10.1038/srep23479. PMID: 27010359; PMCID: PMC4806302.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  300833-95-8