(S,R,S)-AHPC-isobutyl acetate-methanesulfonothioate-Me-C10-NH2 (TFA)

• UNSPSC Description:

  (S,R,S)-AHPC-isobutyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is a part of PROTAC BRD4 Degrader-12 (HY-138635)[1].

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/s-r-s-ahpc-isobutyl-acetate-methanesulfonothioate-me-c10-nh2-tfa.html

• Smiles:

  CS(=O)(S[C@@H](COC(O[C@H](C1)CN(C([C@@H](NC(CCCCCCCCCCN)=O)C(C)(C)C)=O)[C@@H]1C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)=O)C)=O.OC(C(F)(F)F)=O

• Molecular Weight:

  924.12

• References & Citations:

  [1]Dragovich PS, et al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.

• Shipping Conditions:

  Blue Ice