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Rofecoxib (Standard)

CAT: 0804-HY-17372R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17372R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rofecoxib (Standard) is the analytical standard of Rofecoxib. This product is intended for research and analytical applications. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells) .
CAS Number
162011-90-7
Product Name Alternative
MK 966 (Standard)
UNSPSC
12352005
Target
COX; Reference Standards
Type
Reference Standards
Related Pathways
Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/rofecoxib-standard.html
Smiles
O=C1OCC(C2=CC=C(S(=O)(C)=O)C=C2)=C1C3=CC=CC=C3
Molecular Formula
C17H14O4S
Molecular Weight
314.36
References & Citations
[1]Rofecoxib, et al. Rofecoxib [Vioxx, MK-0966; 4- (4'-methylsulfonylphenyl) -3-phenyl-2- (5H) -furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. J Pharmacol Exp Ther. 1999 Aug;290 (2) :551-60.|[2]Liu NN, et al. Rofecoxib inhibits retinal neovascularization via down regulation of cyclooxygenase-2 and vascular endothelial growth factor expression. Clin Exp Ophthalmol. 2015 Jul;43 (5) :458-65.|[3]Stoppoloni D, et al. Synergistic effect of gefitinib and rofecoxib in mesothelioma cells. Mol Cancer. 2010 Feb 2;9:27.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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