Zidovudine

CAT: 0804-HY-17413-01Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-17413-01Size:100 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.

CAS Number

30516-87-1

Product Name Alternative

Azidothymidine; AZT; ZDV

UNSPSC

12352005

Hazard Statement

H351

Target

CRISPR/Cas9; HIV

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Zidovudine.html

Purity

99.97

Solubility

DMSO : ≥ 100 mg/mL|H2O : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC[C@@H]1[C@@H](N=[N+]=[N-])C[C@H](N2C(NC(C(C)=C2)=O)=O)O1

Molecular Formula

C10H13N5O4

Molecular Weight

267.24

Precautions

H351

References & Citations

[1]Gray LR, et al. The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes. PLoS One. 2013 Apr 16;8 (4) :e62196.|[2]Hou P, et al. Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection. Sci Rep. 2015 Oct 20;5:15577.|[3]Mizutani T, et al. Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2015 Nov;56 (12) :7122-9.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

HIV-1

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B2221-100	Zidovudine
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