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Barusiban

CAT: 0804-HY-P3516Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P3516Size:1 Each
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Description
Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (Ki=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research[1][2][3].
CAS Number
285571-64-4
Product Name Alternative
FE-200440
UNSPSC
12352209
Target
Oxytocin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/barusiban.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@](C(N[C@@](C(N[C@H](C(N[C@@H](CCSCCC(N1)=O)C(N(C)[C@H](CO)CCCN)=O)=O)CC(N)=O)=O)([H])[C@H](C)CC)=O)([H])[C@@H](C)CC)[C@H]1CC2=CNC3=CC=CC=C23
Molecular Formula
C40H63N9O8S
Molecular Weight
830.05
References & Citations
[1]Helmer H, et al. Barusiban, a selective oxytocin receptor antagonist: placental transfer in rabbit, monkey, and human†. Biol Reprod. 2020 Jun 23;103 (1) :135-143.|[2]Reinheimer TM, et al. Barusiban, a new highly potent and long-acting oxytocin antagonist: pharmacokinetic and pharmacodynamic comparison with atosiban in a cynomolgus monkey model of preterm labor. J Clin Endocrinol Metab. 2005 Apr;90 (4) :2275-81.|[3]Gimpl G, et al. Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin. Eur J Pharmacol. 2005 Mar 7;510 (1-2) :9-16.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 2

Alternative Products

CatalogName
T69504-01Barusiban

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