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Anisomycin

CAT: 0804-HY-18982-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18982-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system[1]. Anisomycin is a JNK activator, which increases phospho-JNK[2][3]. Anisomycin is a bacterial antibiotic[4].
CAS Number
22862-76-6
Product Name Alternative
Flagecidin; Wuningmeisu C
UNSPSC
12352005
Hazard Statement
H301
Target
Antibiotic; Apoptosis; Bacterial; DNA/RNA Synthesis; JNK; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Anisomycin.html
Concentration
10mM
Purity
99.82
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 4 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@@H]1[C@@H](OC(C)=O)[C@@H](CC2=CC=C(OC)C=C2)NC1
Molecular Formula
C14H19NO4
Molecular Weight
265.31
Precautions
H301
References & Citations
[1]Lu Z, et al. Colistin-induced autophagy and apoptosis involves the JNK-Bcl2-Bax signaling pathway and JNK-p53-ROS positive feedback loop in PC-12 cells.|[2]Zhengle Tang, et al. In vivo toxicological evaluation of Anisomycin. Toxicol Lett. 2012 Jan 5;208 (1) :1-11.|[3]Gao X, et al. Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium. Cardiovasc Res. 2018 Apr 1;114 (5) :737-746.|[4]Synthesis Marina Macías-Silva, et al. Anisomycin is a Multifunctional Drug: More than Just a Tool to Inhibit Protein. Current Chemical Biology, 2010, 4, 124-132.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
JNK

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CatalogName
B6674-5.1Anisomycin

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