TLR7/8/9-IN-1

TLR7/8/9-IN-1

• CAS Number: 2180127-82-4
• UNSPSC Description: TLR7/8/9-IN-1 is a potent and orally bioavailable small molecule antagonist (IC50 = 43 nM) of Toll-like receptors 7/8/9 (TLR7/8/9).
• Target Antigen: Toll-like Receptor (TLR)
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/tlr7-8-9-in-1.html
• Purity: 98.51
• Solubility: DMSO : 83.33 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: CNCCN1CCC(C2=CC3=C(NC(C4=CC=C(OC)C(OC)=C4)=C3C(C)C)C=C2)CC1
• Molecular Weight: 435.60
• References & Citations: [1]Mussari CP, et al. Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9). ACS Med Chem Lett. 2020 Jul 29;11(9):1751-1758.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported