S1P1 agonist III

S1P1 agonist III

• CAS Number: 1324003-64-6
• UNSPSC Description: S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3. IC50 value: 18 nM(EC50) [1] Target: S1P1 agonist When dosed orally at 1 and 3 mg/kg, the azahydroxymethyl analogue 22(HY-12835) achieved statistically significant lowering of circulating blood lymphocytes 24 h postdose. In rats, a dose-proportional increase in exposure was measured when 22(HY-12835) was dosed orally at 2 and 100 mg/kg. 22 displayed excellent pharmacokinetic parameters with low clearance (CL = 0.11 L/h/kg), long mean residence time (40 h), and good oral bioavailability (F = 67%).
• Target Antigen: LPL Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/s1p1-agonist-iii.html
• Purity: 99.64
• Solubility: DMSO : 62.5 mg/mL (ultrasonic)
• Smiles: COC1=CC=NC=C1C(NC(NC2=CC(C(F)(F)F)=C(C3=CC=CC=C3)C=C2)=O)=O
• Molecular Weight: 415.37
• References & Citations: [1]Harrington PE, et al. Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core. ACS Med Chem Lett. 2011 Nov 23;3(1):74-8.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported