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MPI_5a

CAT: 0804-HY-113957-01Size: 1 mg (16.7 mM x 200 μL in Acetonitrile)Dry Ice: NoHazardous: No
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CAT#:0804-HY-113957-01Size:1 mg (16.7 mM x 200 μL in Acetonitrile)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MPI_5a is a potent and selective HDAC6 inhibitor (IC50=36 nM) . MPI_5a weakly inhibits other HDAC isoforms. MPI_5a inhibits acyl-tubulin accumulation in cells with an IC50 value of 210 nM[1].
CAS Number
1259296-46-2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mpi-5a.html
Concentration
16.7 mM * 1 mL in Acetonitrile
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=C(CN(C(C3=CC=CN3C)=O)CC2)C=C1)NO
Molecular Formula
C16H17N3O3
Molecular Weight
299.32
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Blackburn C, et al. Potent histone deacetylase inhibitors derived from 4- (aminomethyl) -N-hydroxybenzamide with high selectivity for the HDAC6 isoform. J Med Chem. 2013 Sep 26;56 (18) :7201-11.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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