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HLY78

CAT: 0804-HY-122816-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122816-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HLY78, a Lycorine derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research[1][2][3].
CAS Number
854847-61-3
UNSPSC
12352005
Hazard Statement
H410
Target
Apoptosis; Wnt; β-catenin
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/hly78.html
Purity
98.44
Solubility
DMSO : 26 mg/mL (ultrasonic)
Smiles
CCC1=CC=CC2=C1N(CC3=CC4=C(C=C32)OCO4)C
Molecular Formula
C17H17NO2
Molecular Weight
267.32
Precautions
H410
References & Citations
[1]Wang S, et al. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9 (9) :579-85.|[2]Luo X, et al. HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3β/β-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats. Neurosci Bull. 2020 Oct;36 (10) :1171-1181.|[3]Ma Y, et al. Dihydroartemisinin suppresses proliferation, migration, the Wnt/β-catenin pathway and EMT via TNKS in gastric cancer. Oncol Lett. 2021 Oct;22 (4) :688.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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