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Bid BH3 peptide

CAT: 0804-HY-P10614Size: 1 EachDry Ice: NoHazardous: No
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Description
Bid BH3 peptide is a small peptide derived from Bid protein that can bind and activate the pro-apoptotic proteins Bax and Bak, leading to mitochondrial outer membrane permeabilization (MOMP) and apoptosis. Bid BH3 peptide can be used to study mitochondrial bioenergetics[1].
CAS Number
300349-78-4
UNSPSC
12352209
Target
Apoptosis; Bcl-2 Family
Type
Peptides
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/bid-bh3-peptide.html
Smiles
N=C(N)NCCC[C@H](N)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC1=CN=CN1)=O)=O)=O)=O)=O
Molecular Formula
C74H127N29O24S
Molecular Weight
1839.05
References & Citations
[1]Gonzalvez F, et al. tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak[J]. Cell Death & Differentiation, 2005, 12 (6) : 614-626.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

Bid BH3 Peptide
CAS Number300349-78-4
PubChem CID91936585
IUPAC Name(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-4-amino-2-[[(2S)-2-amino-5-carbamimidamidopentanoyl]amino]-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-carboxypropanoyl]amino]-5-carbamimidamidopentanoic acid
Molecular FormulaC74H127N29O24S
Molecular Weight1839.0
XLogP-11.1
Topological Polar Surface Area921
Hydrogen Bond Donor Count32
Hydrogen Bond Acceptor Count30
Rotatable Bond Count66
Heavy Atom Count128
Formal Charge0
Complexity3870
SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCCNC(=N)N)N
InChI
InChI=1S/C74H127N29O24S/c1-10-35(6)56(103-67(122)46(26-51(77)106)97-59(114)39(75)14-11-20-85-72(78)79)70(125)91-37(8)58(113)93-40(15-12-21-86-73(80)81)60(115)99-45(25-38-29-84-32-89-38)64(119)98-44(24-33(2)3)63(118)90-36(7)57(112)94-41(17-18-50(76)105)62(117)102-55(34(4)5)69(124)88-30-52(107)92-47(27-53(108)109)65(120)101-49(31-104)68(123)95-42(19-23-128-9)61(116)100-48(28-54(110)111)66(121)96-43(71(126)127)16-13-22-87-74(82)83/h29,32-37,39-49,55-56,104H,10-28,30-31,75H2,1-9H3,(H2,76,105)(H2,77,106)(H,84,89)(H,88,124)(H,90,118)(H,91,125)(H,92,107)(H,93,113)(H,94,112)(H,95,123)(H,96,121)(H,97,114)(H,98,119)(H,99,115)(H,100,116)(H,101,120)(H,102,117)(H,103,122)(H,108,109)(H,110,111)(H,126,127)(H4,78,79,85)(H4,80,81,86)(H4,82,83,87)/t35-,36-,37-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,55-,56-/m0/s1
InChIKey
XVCSJGXTFKBGFT-CJNKUVPHSA-N
Chemical Structure
2D Structure
2D structure of Bid BH3 Peptide
CAS: 300349-78-4
CID: 91936585
Formula: C74H127N29O24S
MW: 1839.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1839.0
XLogP3-11.1
Hydrogen Bond Donor Count32
Hydrogen Bond Acceptor Count30
Rotatable Bond Count66
Exact Mass1837.9329472
Monoisotopic Mass1837.9329472
Topological Polar Surface Area921 Ų
Heavy Atom Count128
Formal Charge0
Complexity3870
Isotope Atom Count0
Defined Atom Stereocenter Count16
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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