2′-O-Methyl-8-methyl guanosine

2′-O-Methyl-8-methyl guanosine

• CAS Number: 2306782-64-7
• UNSPSC Description: 2′-O-Methyl-8-methyl guanosine (m8Gm) is a Z-form RNA stabilizer. 2′-O-Methyl-8-methyl guanosine can markedly stabilize the Z-RNA at low salt conditions[1]. m8Gm-contained oligonucleotides stabilize the Z-DNA under low salt conditions[2].
• Target Antigen: Others
• Type: Oligonucleotides
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/2-o-methyl-8-methyl-guanosine.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O[C@H]1[C@@H](OC)[C@H](N2C(NC(N)=NC3=O)=C3N=C2C)O[C@@H]1CO
• Molecular Weight: 311.29
• References & Citations: [1]Balasubramaniyam T, Ishizuka T, Xu Y. Stability and properties of Z-DNA containing artificial nucleobase 2'-O-methyl-8-methyl guanosine. Bioorg Med Chem. 2019;27(2):364-369.|[2]Balasubramaniyam T, Ishizuka T, Xiao CD, Bao HL, Xu Y. 2'-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA. Molecules. 2018;23(10):2572.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported