TAM558

• Description:

  TAM558 is a payload molecule used for the synthesis of OMTX705. OMTX705 is a humanized anti-fibroblast-activating protein (FAP) antibody conjugated to the cytolysin TAM470 (HY-148128), with antitumor activity[1].

• UNSPSC:

  12352203

• Target:

  Drug-Linker Conjugates for ADC

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tam558.html

• Purity:

  99.29

• Solubility:

  DMSO : ≥ 50 mg/mL

• Smiles:

  O=C([C@@H]1N(CCCC1)C)N[C@@H]([C@@H](C)CC)C(N(CCC)[C@@H](C(C)C)C[C@H](C2=NC(C(N[C@H](C[C@H](C)C(NNC(OCCOCCOCCOCCNC(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=C(C=C5)O)=O)=CS2)OCCC)=O

• Molecular Formula:

  C79H122N14O19S

• Molecular Weight:

  1603.96

• References & Citations:

  [1]Fabre M, et al. OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models. Clin Cancer Res. 2020 Jul 1;26 (13) :3420-3430.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• CAS Number:

  [1802499-21-3]