Methoxy-X04

• Description:

  Methoxy-X04 is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques. Methoxy-X04 retains in vitro binding affinity for amyloid b (Ab) fibrils (Ki= 26.8 nM) . Methoxy-X04 is fluorescent and stains plaques, tangles, and cerebrovascular amyloid in postmortem sections of AD brain with good specificity[1][2].

• UNSPSC:

  12171500

• Hazard Statement:

  H315, H319

• Target:

  Amyloid-β

• Type:

  Dye Reagents

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/methoxy-x04.html

• Concentration:

  10mM

• Purity:

  98.47

• Solubility:

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  COC1=CC (/C=C/C2=CC=C (O) C=C2) =CC=C1/C=C/C3=CC=C (O) C=C3

• Molecular Formula:

  C23H20O3

• Molecular Weight:

  344.40

• Precautions:

  H315, H319

• References & Citations:

  [1]Bisht K, et al. Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques. J Vis Exp. 2016 Jun 1; (112) :54060.|[2]Klunk WE, et al. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol. 2002 Sep;61 (9) :797-805.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Dye Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  863918-78-9