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Methoxy-X04

CAT: 0804-HY-103240-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103240-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methoxy-X04 is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques. Methoxy-X04 retains in vitro binding affinity for amyloid b (Ab) fibrils (Ki= 26.8 nM) . Methoxy-X04 is fluorescent and stains plaques, tangles, and cerebrovascular amyloid in postmortem sections of AD brain with good specificity[1][2].
CAS Number
863918-78-9
UNSPSC
12171500
Hazard Statement
H315, H319
Target
Amyloid-β
Type
Dye Reagents
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/methoxy-x04.html
Concentration
10mM
Purity
98.47
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
COC1=CC(/C=C/C2=CC=C(O)C=C2)=CC=C1/C=C/C3=CC=C(O)C=C3
Molecular Formula
C23H20O3
Molecular Weight
344.40
Precautions
H315, H319
References & Citations
[1]Bisht K, et al. Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques. J Vis Exp. 2016 Jun 1; (112) :54060.|[2]Klunk WE, et al. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol. 2002 Sep;61 (9) :797-805.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

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