Methoxy-X04

• Description :

  Methoxy-X04 is a fluorescent dye that crosses the blood-brain barrier and selectively binds to beta-pleated sheets found in dense core amyloid Aβ plaques. Methoxy-X04 retains in vitro binding affinity for amyloid b (Ab) fibrils (Ki= 26.8 nM) . Methoxy-X04 is fluorescent and stains plaques, tangles, and cerebrovascular amyloid in postmortem sections of AD brain with good specificity[1][2].

• UNSPSC :

  12171500

• Hazard Statement :

  H315, H319

• Target :

  Amyloid-β

• Type :

  Dye Reagents

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/methoxy-x04.html

• Concentration :

  10mM

• Purity :

  98.47

• Solubility :

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles :

  COC1=CC(/C=C/C2=CC=C(O)C=C2)=CC=C1/C=C/C3=CC=C(O)C=C3

• Molecular Formula :

  C23H20O3

• Molecular Weight :

  344.40

• Precautions :

  H315, H319

• References & Citations :

  [1]Bisht K, et al. Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques. J Vis Exp. 2016 Jun 1; (112) :54060.|[2]Klunk WE, et al. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol. 2002 Sep;61 (9) :797-805.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Dye Reagents

• Clinical Information :

  No Development Reported

• CAS Number :

  [863918-78-9]