Lysophosphatidic Acid Receptor 1 (EDG2)

• Background:

  Endothelial cell differentiation gene-2 (EDG-2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG-2, also known as lysophospholipid receptor A1, Vzg-1, mrec1.3 or GPCR26, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduce decreases in c[AMP]i through Gi and increases in [Ca2+]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain Human malignant T cell lines. EDG-2 receptors (with EDG-4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.

• Synonyms:

  EDG-2 transfected Cell lysate

• UniProt:

  Q92633

• Conjugation:

  Unconjugated

• Type:

  Control Lysate

• Applications:

  WB

• Field of Research:

  Ancillary Reagents

• Assay Principle:

  For use as a positive control with Exalpha's EDG2 (LPA1) polyclonal antibody (Cat. No. C174P) for Western blot analysis.

• Stability:

  See expiration date on vial

• Concentration:

  See vial for Concentration

• Form:

  Provided in 10% glycerol, 0,063 M Tris-HCl (pH 6,8), 2% SDS and 0,002% bromophenol blue, 5% 2-mercaptoethanol

• Precautions:

  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

• Shipping Conditions:

  Ambient Temperature, freeze upon arrival

• Storage Conditions:

  Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

• Functional Analysis:

  WB