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LY404039

CAT: 0804-HY-50906-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-50906-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY404039 is a potent, selective and orally active mGluR2 and mGluR3 agonist with Kis of 149 nM and 92 nM for recombinant human mGluR2 and mGluR3, respectively. LY404039 shows >100-fold selectivity for mGluR2/3 over other receptors/transproters. LY404039 has antipsychotic and anxiolytic effects[1].
CAS Number
635318-11-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/LY404039.html
Purity
98.0
Solubility
DMSO : 3.84 mg/mL (ultrasonic; warming) |H2O : 5.2 mg/mL (ultrasonic; adjust pH to 6 with NaOH)
Smiles
O=C([C@]1(N)CS([C@@]2([H])[C@H](C(O)=O)[C@@]12[H])(=O)=O)O
Molecular Formula
C7H9NO6S
Molecular Weight
235.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Linda M Rorick-Kehn, et al. Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-) - (1R,4S,5S,6S) -4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039) . J Pharmacol Exp Ther. 2007 Apr;321 (1) :308-17.|[2]Seeman P. An agonist at glutamate and dopamine D2 receptors, LY404039. Neuropharmacology. 2013 Mar;66:87-8.|[3]Rorick-Kehn LM, et al. In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonistLY404039 in animal models of psychiatric disorders. Psychopharmacology (Berl) . 2007 Jul;193 (1) :121-36.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
MGluR2; mGluR3

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