Norgestrel

• Description:

  Norgestrel is a synthetic analog of progesterone, a compound commonly found in oral contraceptive pill, and a powerful neuroprotective antioxidant, preventing light-induced ROS in photoreceptor cells, and cell death[1][2]. Norgestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H335

• Target:

  Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/norgestrel.html

• Purity:

  99.93

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1CC[C@@]2 ([H]) C (CC[C@]3 ([H]) [C@]2 ([H]) CC[C@@]4 (CC) [C@@]3 ([H]) CC[C@]4 (C#C) O) =C1

• Molecular Formula:

  C21H28O2

• Molecular Weight:

  312.45

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Wyse Jackson AC, et al. The synthetic progesterone Norgestrel is neuroprotective in stressed photoreceptor-like cellsand retinal explants, mediating its effects via basic fibroblast growth factor, protein kinase A and glycogen synthase kinase 3β signalling. Eur J Neurosci. 2016 Apr;43 (7) :899-911.|[2]Byrne AM, et al. The synthetic progestin norgestrel modulates Nrf2 signaling and acts as an antioxidant in a model of retinal degeneration. Redox Biol. 2016 Dec;10:128-139.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  6533-00-2