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Polmacoxib (Standard)

CAT: 0804-HY-16726RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-16726RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Polmacoxib (Standard) is the analytical standard of Polmacoxib. This product is intended for research and analytical applications. Polmacoxib (CG100649) is a first-in-class, orally active nonsteroidal anti-inflammatory agent (NSAID) which is a dual inhibitor of COX-2 (IC50 around 0.1 μg/ml) and carbonic anhydrase[1]. Polmacoxib inhibits colorectal adenoma and tumor growth in mouse models[2].
CAS Number
301692-76-2
Product Name Alternative
CG100649 (Standard)
UNSPSC
12352005
Target
Carbonic Anhydrase; COX; Reference Standards
Type
Reference Standards
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/polmacoxib-standard.html
Smiles
O=S(C1=CC=C(C(OC2(C)C)=C(C3=CC=CC(F)=C3)C2=O)C=C1)(N)=O
Molecular Formula
C18H16FNO4S
Molecular Weight
361.39
References & Citations
[1]Kim SH, et al. CG100649, a novel COX-2 inhibitor, inhibits colorectal adenoma and carcinoma growth in mouse models. Invest New Drugs. 2014;32 (6) :1105-1112.|[2]Flick AC, et al. Synthetic Approaches to the New Drugs Approved During 2015 [published correction appears in J Med Chem. 2017 Oct 26;60 (20) :8680]. J Med Chem. 2017;60 (15) :6480-6515.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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