M199

• Description :

  M199 is a potent TLR3/TLR9 signaling inhibitor. M199 induces secretion of IL-6, IL-8 and TNFα in human PBMCs. M199 is used as a selective inducer of the immune response[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Interleukin Related; TNF Receptor; Toll-like Receptor (TLR)

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/m199.html

• Purity :

  98.55

• Solubility :

  DMSO : 5.83 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(NCC)NC1=CC2=C(N=C3C=CC=CC3=C2C=C1)C

• Molecular Formula :

  C17H17N3O

• Molecular Weight :

  279.34

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Natalija Knežević Teofilović, et al. 1-ethyl-3- (6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro. Bioorg Med Chem Lett. 2017 Apr 1;27 (7) :1530-1537.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IL-6; IL-8; TLR3; TLR9

• CAS Number :

  [1051933-86-8]