27-O-(tert-Butyldimethylsilyl)withaferin A

27-O-(tert-Butyldimethylsilyl)withaferin A

• CAS Number: 1392820-18-6
• UNSPSC Description: 27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells[1].
• Target Antigen: Apoptosis
• Type: Natural Products
• Related Pathways: Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/27-o-tert-butyldimethylsilyl-withaferin-a.html
• Solubility: 10 mM in DMSO
• Smiles: C[C@]12[C@@]3([C@H](C=CC2=O)O)[C@](C[C@]4([H])[C@]1([H])CC[C@]5([C@@]4([H])CC[C@]5([H])[C@@H]([C@@]6([H])CC(C)=C(C(O6)=O)CO[Si](C)(C)C(C)(C)C)C)C)([H])O3
• Molecular Weight: 584.86
• References & Citations: [1]Gabriel G Llanos, et al. Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells. Eur J Med Chem. 2012 Aug;54:499-511.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported