DiMNF

• Description:

  DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent[1].

• Product Name Alternative:

  3',4'-Dimethoxy-αNF

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  Aryl Hydrocarbon Receptor

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/dimnf.html

• Concentration:

  10mM

• Purity:

  98.46

• Solubility:

  DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 70°C)

• Smiles:

  O=C1C2=CC=C3C=CC=CC3=C2OC(C4=CC=C(OC)C(OC)=C4)=C1

• Molecular Formula:

  C21H16O4

• Molecular Weight:

  332.35

• Precautions:

  H301

• References & Citations:

  [1]Murray IA, et al. Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone. Mol Pharmacol. 2011 Mar;79 (3) :508-19.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [14756-24-2]