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Chlorobutanol

CAT: 0804-HY-B1263-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1263-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Chlorobutanol is an orally active and potent inhibitor of platelet aggregation and release and a pharmaceutical preservative with antibacterial activity. Chlorobutanol inhibits thromboxane B2 formation, ATP release, and elevation of cytosolic free calcium caused by collagen, ADP, epinephrine, arachidonic acid and thrombin. Chlorobutanol is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol is widely used in food and cosmetic industry[1][2][3][4].
CAS Number
57-15-8
UNSPSC
12352211
Hazard Statement
H302
Target
Bacterial; Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/chlorobutanol.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(O)(C)C(Cl)(Cl)Cl
Molecular Formula
C4H7Cl3O
Molecular Weight
177.46
Precautions
H302
References & Citations
[1]Smoak IW, et al. Chlorobutanol: maternal serum levels and placental transfer in the mouse. Vet Hum Toxicol. 1997 Oct;39 (5) :287-90.|[2]Friesen WT, et al. The antibacterial stability of chlorobutanol stored in polyethylene bottles. Am J Hosp Pharm. 1971 Jul;28 (7) :507-12.|[3]Chen SL, et al. Chlorobutanol, a preservative of desmopressin, inhibits human platelet aggregation and release in vitro. Thromb Haemost. 1990 Nov 30;64 (3) :473-7.|[4]Fischer M. Effects of chlorobutanol on primary and secondary endings of isolated cat muscle spindles. Brain Res. 2000 Jan 31;854 (1-2) :106-21.|[5]Jeong D, et al. In Vivo Evaluation of the Oral Toxicity of the Chlorobutanol. Toxics. 2022 Jan 7;10 (1) :24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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