α-Bungarotoxin

α-Bungarotoxin

• CAS Number: 11032-79-4
• UNSPSC Description: α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC50 of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM[1][2].
• Target Antigen: nAChR
• Type: Peptides
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/α-bungarotoxin.html
• Purity: 99.0
• Solubility: H2O : ≥ 50 mg/mL
• Smiles: O=C(N[C@@H](C(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCSC)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(NC4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC5=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@H]5CC6=CC=CC=C6)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC7=O)C(N[C@@H](CC8=CNC=N8)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N9[C@@H](CCC9)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(N)=O)C(N%10[C@@H](CCC%10)C(N[C@@H](CC%11=CNC=N%11)C(N%12[C@@H](CCC%12)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N%13[C@@H](CCC%13)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%14=O)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@H]%14CCCCN)=O)=O)=O)=O)=O)NC%15=O)C(N%16[C@@H](CCC%16)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N%17[C@@H](CCC%17)C(N[C@@H](CC%18=CC=C(C=C%18)O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@H]%15[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC4=O)C(N%19[C@@H](CCC%19)C(N%20[C@@H](CCC%20)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@H]7CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)N
• Molecular Weight: 7984.12
• References & Citations: [1]Hannan S, et al. Snake neurotoxin α-bungarotoxin is an antagonist at native GABA(A) receptors. Neuropharmacology. 2015;93:28-40.|[2]López MG, et al. Unmasking the functions of the chromaffin cell alpha7 nicotinic receptor by using short pulses of acetylcholine and selective blockers. Proc Natl Acad Sci U S A. 1998;95(24):14184-14189.|[3]Balass M, et al. The alpha-bungarotoxin binding site on the nicotinic acetylcholine receptor: analysis using a phage-epitope library. Proc Natl Acad Sci U S A. 1997;94(12):6054-6058.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported