Dieugenol

CAT: 0804-HY-130743-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-130743-01Size:1 mg

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Description

Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC50s=15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.2 Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.

CAS Number

4433-08-3

Product Name Alternative

Bis-eugenol; Dehydrodieugenol

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dieugenol.html

Smiles

OC1=C(OC)C=C(CC=C)C=C1C2=CC(CC=C)=CC(OC)=C2O

Molecular Formula

C20H22O4

Molecular Weight

326.39

References & Citations

[1]Ogata, et al. Antioxidant activity of eugenol and related monomeric and dimeric compounds. Chem. Pharm. Bull. (Tokyo) 48 (10), 1467-1469 (2000) .

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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