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UK122

CAT: 0804-HY-111056-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111056-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50>100 μM) . UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion[1].
CAS Number
940290-58-4
UNSPSC
12352005
Hazard Statement
H302, H400
Target
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/uk122.html
Purity
99.85
Solubility
DMSO : 14.29 mg/mL (ultrasonic)
Smiles
N=C(C1=CC=C(/C=C2N=C(C3=CC=CC=C3)OC/2=O)C=C1)N
Molecular Formula
C17H13N3O2
Molecular Weight
291.30
Precautions
H302, H400
References & Citations
[1]Ming Zhu, et al. Identification of a novel inhibitor of urokinase-type plasminogen activator. Mol Cancer Ther. 2007 Apr;6 (4) :1348-56.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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BA8332-5UK122
GTR19275390-01UK122 hydrochloride
sc-356185UPA Inhibitor II, UK122

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