BB2-50F

• Description :

  BB2-50F is an antimicrobial agent and succinate dehydrogenase and F1Fo-ATP synthase inhibitor. BB2-50F induces ROS. BB2-50F inhibits succinate oxidation and reduces tricarboxylic acid (TCA) cycle activity. BB2-50F inhibits the growth of Mycobacterium tuberculosis H37Rv and its auxotrophic, attenuated derivative mc2 6230 (ΔRD1, ΔpanCD) with an MIC of 8 μM[1].

• CAS Number :

  [2226086-65-1]

• UNSPSC :

  12352005

• Target :

  Bacterial; Reactive Oxygen Species (ROS) ; Succinate Dehydrogenase

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/bb2-50f.html

• Purity :

  99.52

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(NC(N)=N)C1=NC(C2=CC3=C(O2)C=CC=C3)=C(N4CCCCCC4)N=C1N

• Molecular Formula :

  C20H23N7O2

• Molecular Weight :

  393.44

• References & Citations :

  [1]Adolph C, et al. A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis. Cell Chem Biol. 2023 Dec 21:S2451-9456 (23) 00432-4.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported