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BB2-50F

CAT: 0804-HY-162142-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-162142-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BB2-50F is an antimicrobial agent and succinate dehydrogenase and F1Fo-ATP synthase inhibitor. BB2-50F induces ROS. BB2-50F inhibits succinate oxidation and reduces tricarboxylic acid (TCA) cycle activity. BB2-50F inhibits the growth of Mycobacterium tuberculosis H37Rv and its auxotrophic, attenuated derivative mc2 6230 (ΔRD1, ΔpanCD) with an MIC of 8 μM[1].
CAS Number
2226086-65-1
UNSPSC
12352005
Target
Bacterial; Reactive Oxygen Species (ROS) ; Succinate Dehydrogenase
Type
Reference compound
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/bb2-50f.html
Purity
99.52
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC(N)=N)C1=NC(C2=CC3=C(O2)C=CC=C3)=C(N4CCCCCC4)N=C1N
Molecular Formula
C20H23N7O2
Molecular Weight
393.44
References & Citations
[1]Adolph C, et al. A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis. Cell Chem Biol. 2023 Dec 21:S2451-9456 (23) 00432-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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