Lenalidomide-C5-NH2 (hydrochloride)

Lenalidomide-C5-NH2 (hydrochloride)

• CAS Number: 2595367-27-2
• UNSPSC Description: Lenalidomide-C5-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader[1][2].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/lenalidomide-c5-nh2-hydrochloride.html
• Purity: 98.44
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: O=C1C(C=CC=C2CCCCCN)=C2CN1C3C(NC(CC3)=O)=O.Cl
• Molecular Weight: 365.85
• References & Citations: [1]Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.|[2]Yangbing Li, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported