PR280

CAT: 0804-HY-163472Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-163472Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

PR280 is a potent inhibitor of dihydroceramide desaturase 1 (Des1) (IC50=700 nM) . PR280 forms hydrogen bonds with the amino acid residues of Des1, and its cyclopropenone group may form a coordination with the iron center, thus stabilizing the binding to the active site of Des1 and inhibiting the sphingosine lipid synthesis pathway of dihydroceramide (dhCer) to form ceramide. PR280 can be used in the study of diseases related to sphingosine lipid metabolism, such as cancer and metabolic diseases[1].

UNSPSC

12352005

Target

Dihydroceramide Desaturase 1 (DES1)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pr280.html

Smiles

CCCCCCCC(N[C@H]([C@@H](C1=C(C1=O)CCCCCCCCCCCCC)O)CO)=O

Molecular Formula

C27H49NO4

Molecular Weight

451.68

References & Citations

[1]Rivero P, et al. Targeting dihydroceramide desaturase 1 (Des1) : Syntheses of ceramide analogues with a rigid scaffold, inhibitory assays, and AlphaFold2-assisted structural insights reveal cyclopropenone PR280 as a potent inhibitor[J]. Bioorganic Chemistry, 2024: 107233.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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GTR19262621-01	PR280

PR280

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